Twenty three skeletons have been uncovered lying in two carefully laid out rows on the edge of Charterhouse Square at Farringdon, and are believed to be up to 660 years old.
The scientists are hoping to map the DNA signature of the Plague bacteria and possibly contribute to the discussion regarding what caused the Black Death.
The bones may also be radio carbon dated to try and establish the burial dates. After 650 years, only the skeleton bones remain and do not present any modern-day health risk.
Crossrail Lead Archaeologist Jay Carver said: “This is a highly significant discovery and at the moment we are left with many questions that we hope to answer.
During the past two weeks, Crossrail’s archaeologists uncovered 23 skeletons 2.5 metres below the road that surrounds the gardens in Charterhouse Square.
The depth of the burials, the pottery dated up until 1350 found in the graves and the layout of the skeletons all point to the likelihood that these skeletons were buried in Charterhouse Square during the Black Death Plague around 1349.