Non sedating antihistamines list

Pharmaceutical compositions and methods of using same comprising aspirin, sodium salicylate, salicylamide or acetaminophen, in combination with a non-sedating antihistamine and optionally one or more other active components selected from a decongestant, cough suppressant (antitussive) or expectorant... The usual adult dosage is about 600 mg every four to six hours.

A method for the treatment of cough, cold, cold-like and/or flu symptoms and the discomfort, pain, headache, fever and general malaise associated therewith, in a mammalian organism in need of such treatment comprising administering to such organism the pharmaceutical composition as defined by claim 3.23. The usual dosage is from about 300 mg to 600 mg every three to four hours.

A method for the treatment of cough, cold, cold-like and/or flu symptoms and the discomfort, pain, headache, fever and general malaise associated therewith, in a mammalian organism in need of such treatment comprising administering to such organism the pharmaceutical composition as defined by claim 2.24. Acetaminophen is also known as N-(4-hdroxyhphenyl)acetamide, N-acetyl-p-aminophenol (APAP), p-acetamidophenol or 4'-hydroxyacetanilide and has the following chemical structure: ##STR4## On a milligram for milligram basis the efficacy of acetominophen as an analgesic and antipyretic is widely believed to be equivalent to that of aspirin.

A method for the treatment of an allergic reaction in a mammalian organism in need of such treatment, comprising administering to such organism an allergic symptom relieving effective amount of a composition comprising (i) acetaminophen or pharmaceutically acceptable salt thereof, in combinatory immixture with (ii) at least one of the non-sedating antihistamines, acrivastine, astemizole, azatadine, cetirizine, ketotifen, loratidine, temelastine, terfenadine or pharmaceutically acceptable salt thereof. It is used to treat headache, mild to moderate myalgia, arthralgia, chronic pain from cancer, postpartum pain, postoperative pain, and fever.

Applicants have filed a number of applications concerning cough/cold formulations containing the newer non-steroidal anti-inflammatory drugs. It is the preferred alternative analgesic-antipyretic to aspirin and the newer NSAIDs, particularly in patients who cannot tolerate aspirin, those with a coagulation disorder (e.g., hemophilia), or individuals with a history of peptic ulcer.

These applications which are assigned to Richardson-Vicks, Inc. Unlike aspirin, acetaminophen does not antagonize the effects of uricosuric agents; thus, it may be used in patients with gouty arthritis who are taking a uricosuric.

In the practice of the present invention, the dosage range is from about 300 mg to 2 grams every four to six hours. For this reason, an equivalent amount of sodium bicarbonate is sometimes employed along with sodium salicylate. The sodium salt tends to cause gastric irritation due to the liberation of free salicylic acid by the acid gastric juice. Sodium salicylate is about 1/3 less potent, on a weight basis, than aspirin, and therefore the equivalent analgesic dose is somewhat higher. As is the case with aspirin, sodium salicylate is widely employed for the relief of pain and the reduction of fever. Another salicylic acid derivative, sodium salicylate, has the chemical structure: ##STR2## Sodium salicylate is also known as the monosodium salt of 2-hydroxybenzoic acid or monosodium salicylate.

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